Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia낮은 BALF CD4 T 세포 수는 중환자의 covid-19 폐렴에서 발관 실패 및 사망률과 관련이 있습니다Article Published on 2022-12-012022-09-11 Journal: Annals of Medicine [Category] 바이오마커, 진단, [키워드] affected alveolar alveolar macrophage analysed average BALF BALF CD4 T-cells count baseline Biomarker bivariate analysis Bronchoalveolar lavage fluid caspase caspase-3 cause CD4 CD4 T cell CD4 T-cell Characteristics clinical Clinical characteristics conducted COVID-19 COVID-19 patients COVID-19 pneumonia COVID-19 pneumonia patient COVID-19 pneumonia patients Critically ill critically ill COVID-19 patients Critically ill COVID-19 pneumonia D-dimer D-dimer level eight enrolled extubation failure. groups help IL-17 IL-6 immunopathology IMPROVE Indonesia intubation Invasive mechanical ventilation Laboratory lung Macrophage material Mortality no significant difference no significant differences outcome Patient performed Pneumonia profile Referral reported right lung severe pneumonia severity significant differences significantly survived T-cells Tertiary Tregs understanding was performed were measured [DOI] 10.1080/07853890.2022.2095012 PMC 바로가기 [Article Type] Article
Distinct immune responses in the early phase to natural SARS-CoV-2 infection or vaccinationArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, [키워드] acute phase acute respiratory syndrome analyzed antibody Antibody Response coronavirus cytokine cytokine expression cytokine level Cytokines dose early phase elicited expression healthy IgA antibody immune response immunization implication inactivated Inactivated vaccine Inactivated Vaccines infected individuals natural infection nucleocapsid postvaccination Protein Reinfection response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 vaccine SARS-CoV-2 vaccines serological significant differences two groups vaccination vaccination. Vaccines variety viral infection [DOI] 10.1002/jmv.28034 PMC 바로가기
Remdesivir Plus Dexamethasone Versus Dexamethasone Alone for the Treatment of Coronavirus Disease 2019 (COVID-19) Patients Requiring Supplemental O2 Therapy: A Prospective Controlled Nonrandomized Study코로나바이러스 질병 2019(COVID-19) 환자 치료를 위한 렘데시비르 플러스 덱사메타손 대 덱사메타손 단독 요법: 보충 O2 요법이 필요한 환자: 전향적 통제된 비무작위 연구Controlled Clinical Trial Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 임상, 치료제, [키워드] 30-Day mortality Antiviral baseline calculated clinical outcomes cohorts Combination Controlled coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient CRP D-dimer Dexamethasone drug effective Endpoint enrolled evaluate evaluated faster fibrinogen FiO2 group groups Hospitalization IMPROVE independent Inflammatory inflammatory markers Kaplan-Meier Kaplan-Meier curve Kaplan-Meier curves laboratory characteristics log-rank test median Mortality neutrophil neutrophil/lymphocyte ratio no differences occurred primary endpoint primary endpoints Prospective reducing mortality reduction in reduction in mortality Remdesivir Respiratory failure Respiratory function Sample size SARS-CoV-2 clearance secondary Secondary endpoints shown significant difference significant differences survival the log-rank test therapy treat Treatment viral clearance Viral clearance. were used [DOI] 10.1093/cid/ciac014 PMC 바로가기 [Article Type] Controlled Clinical Trial
Detection of Intestinal Dysbiosis in Post-COVID-19 Patients One to Eight Months after Acute Disease Resolution급성 질환 해결 후 1~8개월 후 코로나19 환자의 장내 세균총 이상 감지Article Published on 2022-08-172022-09-11 Journal: International Journal of Environmental Research an [Category] 치료제, [키워드] acute COVID-19 acute disease acute phase adaptive immune responses addition alopecia anti-SARS-CoV-2 antibody Antibiotic therapy Antibiotics Anxiety bidirectional Bifidobacterium C-reactive protein Clinical data clinical manifestations controls COVID-19 severity Cytokine storm Depression Desulfovibrio detection disease DNA Dysbiosis Dyspnea evaluate fatigue Hypothesis immune response immune responses Immune status Interaction intestinal intestinal microbiota memory memory loss microbes microbiota modulating modulation Month myalgia pandemic Patient post-COVID-19 Post-COVID-19 patients Prevotella quantified reported symptoms Resolution Sequelae. sequenced severity significant difference significant differences Stool stool samples target the patient Therapeutic approach These data use of antibiotics viral infections with COVID-19 [DOI] 10.3390/ijerph191610189 PMC 바로가기 [Article Type] Article
Association between HLA-C alleles and COVID-19 severity in a pilot study with a Spanish Mediterranean Caucasian cohort스페인 지중해 백인 코호트를 대상으로 한 파일럿 연구에서 HLA-C 대립형질과 COVID-19 심각성 사이의 연관성Article Published on 2022-08-122022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, [키워드] age allele analyzed antiviral response association Asymptomatic cause Cell cell surface class Clinical characteristics clinical presentation Clinical presentations Cohort Comorbidity contrary COVID-19 COVID-19 severity Critical described determine disease epitope Epitopes expressed Factor fatal disease Gender groups HLA HLA allele HLA alleles HLA class I HLA-A HLA-B HLA-B allele HLA-B alleles HLA-C HLA-C allele HLA-C alleles HLA-C1 Host hyperinflammatory state immune response individual Infection involved KIR gene male management mechanism Mild mild infection no significant difference no significant differences outcomes pandemic peptide peptides pilot study recruited SARS-CoV-2 protein SARS-CoV-2 proteins significant difference significant differences small sample size Spain Spanish T cells β2-microglobulin [DOI] 10.1371/journal.pone.0272867 PMC 바로가기 [Article Type] Article
Association between COVID-19 and Sick Leave for Healthcare Workers in a Large Academic Hospital in Southern Italy: An Observational StudyCOVID-19와 남부 이탈리아의 대규모 학술 병원 의료 종사자의 병가 사이의 연관성: 관찰 연구Observational Study Published on 2022-08-052022-09-11 Journal: International Journal of Environmental Research an [Category] SARS, 변종, 임상, [키워드] CAT score changed conducted Coverage COVID-19 decrease evaluate HCWs healthcare healthcare worker Healthcare workers increase in involved Italy management observational study omicron Omicron variant optimization pandemic Perception public health questionnaire Regulation SARS-CoV-2 shown sick sick leave significant difference significant differences South subject Symptom Symptoms Symptoms. university hospital vaccination variant worker [DOI] 10.3390/ijerph19159670 PMC 바로가기 [Article Type] Observational Study
The influence of SARS-CoV-2 on semen parameters of infected infertile male in comparison with those that noninfected감염되지 않은 남성과 비교하여 감염된 불임 남성의 정액 매개변수에 대한 SARS-CoV-2의 영향Article Published on 2022-08-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 치료기술, [키워드] address age alteration caused Computer-assisted semen analysis coronavirus disease count COVID COVID-19 determine disease Infection Infectious disease infertility Inflammation involved kidney lung male male fertility moderate morphology organs parameter parameters Patient patients progression reported SARS CoV SARS CoV-2 SARS-CoV-2 Semen Semen analysis Seminal fluid severity severity of COVID-19 shown significant difference significant differences Sperm sperm count Spread Teaching Testis testis. the WHO vaccination virus Volume was performed was recorded were infected while [DOI] 10.1002/jcla.24568 PMC 바로가기 [Article Type] Article
Gestational SARS-CoV-2 infection is associated with placental expression of immune and trophoblast genes임신성 SARS-CoV-2 감염은 면역 및 영양막 유전자의 태반 발현과 관련이 있습니다Article Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] absence age analysis antibody Birth CGB3 change contribute correlation CXCL10 DDX58 decreased expression during pregnancy Effect evaluate expression feature Features fetus Fisher Gene Expression Generation gestational age group groups Health histologic Histopathology IgG IgG antibody immune immune gene immune genes increased expression Infant Infants Linear regression linear regression models Maternal median molecular Mount Sinai Mount Sinai Health System NanoString nasal swab New York City no significant differences not differ offspring outcome participant Participants performed Placenta placental Placentas positive positive RT-PCR Pregnancy pregnant prospective cohort study PSG3 SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2. serology test severe disease significant difference significant differences Spearman statistical analyses System term the SARS-CoV-2 TLR3 Transmission vertical transmission [DOI] 10.1016/j.placenta.2022.06.017 PMC 바로가기 [Article Type] Article
Interdependencies of cellular and humoral immune responses in heterologous and homologous SARS-CoV-2 vaccination이종 및 동종 SARS-CoV-2 백신 접종에서 세포 및 체액성 면역 반응의 상호 의존성Observational Study Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] Anti-spike Antibody avidity association avidity blood sample Blood samples BNT162b2 booster booster vaccination cellular Cellular immune response cellular immune responses ChAdOx1 ChAdOx1 nCoV-19 group healthcare worker Heterologous homologous humoral Humoral and cellular immune responses humoral immune response humoral responses IgG levels immune immune response immune responses immunization interferon interferon-γ nCoV Neutralizing antibodies neutralizing antibody no significant differences Observational cohort study SARS-CoV-2 SARS-CoV-2 vaccination secondary immunization significant difference significant differences Spike protein T-cell T-cell activation T-cell Response T-cell responses unlikely vaccination vaccination. [DOI] 10.1111/all.15247 PMC 바로가기 [Article Type] Observational Study
NETosis and Nucleosome Biomarkers in Septic Shock and Critical COVID-19 Patients: An Observational Study패혈성 쇼크 및 심각한 COVID-19 환자의 NETosis 및 뉴클레오솜 바이오마커: 관찰 연구Observational Study Published on 2022-07-272022-09-11 Journal: Biomolecules [Category] MERS, 바이오마커, 임상, [키워드] alternative Biomarker Biomarkers cell death conditions Control control subject COVID-19 Critical critical COVID-19 patient critical COVID-19 patients Defense discrimination disease severity evaluate extracellular trap histone ICU Infection Intact intensive care intensive care unit marker matched control mechanism microorganisms MPO myeloperoxidase NET NETosis NETs NETs’ formation neutrophil neutrophil activation neutrophil count Neutrophil elastase Neutrophil extracellular traps Neutrophils normalization Nucleosome nucleosomes P -value p -values patient cohort patients phagocytosis recruited Result SARS-CoV-2 septic Septic shock Septic shock. Significant significant differences Spread subject were measured [DOI] 10.3390/biom12081038 PMC 바로가기 [Article Type] Observational Study